Implication of DNA methylation changes at chromosome 1q21.1 in the brain pathology of Primary Progressive Multiple Sclerosis Searching for molecular markers associated with MS diagnosis, this study identified changes at chromosome 1q21.1 linked to PPMS. DNA methylation of this region is increased in these patients, both compared to healthy controls and to patients with other …
Lifespan Neurodegeneration Of The Human Brain In Multiple Sclerosis Using MRI data from more than 40,000 subjects, this study compares regional brain atrophy in people with MS as compared to normal controls and models its progression over time. The most pronounced atrophy related to MS started in deep grey matter structures (mainly thalamus, pallidum and …
Obesity, Inflammation, and MS We are featuring four preprints this month, which explore the role of obesity and inflammation in MS. The four studies report: A connection between stress and brain aging that is amplified in multiple sclerosis by disease-specific vulnerability factors. A relationship between obesity and MS, which appears to be mediated by neurological …
Featured Preprint Plasma protein profiling of multiple sclerosis using proximity extension assays Jesse Huang et al, Karolinska Institute Summary: To detect traces of disease activity in the periphery and identify low-abundance protein biomarkers, this study conducts an exploratory examination of the plasma proteome of MS using proximity extension technology, a high-sensitivity multiplex PCR-based immunoassay. The authors …
