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Obesity, Inflammation, and MS

We are featuring four preprints this month, which explore the role of obesity and inflammation in MS. The four studies report:

  • A connection between stress and brain aging that is amplified in multiple sclerosis by disease-specific vulnerability factors.
  • A relationship between obesity and MS, which appears to be mediated by neurological and immunological pathways related to processing stress.
  • A possible role for immune-inflammatory pathways in association with mood and chronic-fatigue-like symptoms in about half of RRMS patients.
  • A genetic link between obesity and MS, driven by a causal link between obesity-related genes and MS, but not between MS genes and obesity.

Similar neural pathways link psychological stress and brain health in health and multiple sclerosis

Marc-Andre Schulz et al, Charité – Universitätsmedizin Berlin

fig 1

Neural stress processing, glucocorticoid functioning, and body mass in lean to obese persons with multiple sclerosis

Lil Meyer-Arndt et al,  Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin, Germany 

fig 2

Mood symptoms and chronic fatigue syndrome due to relapsing remitting multiple sclerosis are associated with immune activation and aberrations in the erythron

Abbas F. Almulla et al, Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

fig 3
Get Paid to Read: researchXchange is looking for lead editors with a background in neurology and/or neuroscience for part time, remote work, reading and annotating the latest preprints.

Investigating shared genetic architecture between obesity and multiple sclerosis

Ruijie Zeng Department of Gastroenterology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences

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DropCite provides a network for readers, researchers, and authors to annotate and discuss emerging research, in line, anywhere, any time. The researchXchange tracks the most recent scientific preprints about Multiple Sclerosis. DropCite’s editorial team showcases the most significant preprints along with comments from the research community. Follow the conversation and hear what the experts are saying by clicking on the links below. You are free to sign up to become a member of the DropCite community if you want to join the conversation.

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