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Jessica R. Allanach, et al
Epstein-Barr virus (EBV) has long been recognized as having a role in the etiology of MS, but its centrality became clear a year ago with the release of a paper demonstrating a 32-fold increase in risk associated with prior infection. That revelation means that understanding the mechanisms behind this relationship is critical to defining and addressing the pathophysiology of MS. Can an innovative mouse model provide provide a key tool for this research?
Investigators found that injection of peripheral blood mononuclear cells (PBMCs) from EBV seropositive and RRMS donor exacerbated disease severity in a mouse model of MS
EBV seropositivity was associated with marked differences in the activity of effector T-cells, regulatory T-cells, and B-cells in the mouse model despite absence of the virus. This suggests that EBV infection can lead to prolonged dysregulation of the host immune system.
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